Principal Scientist, Molecular Biology
Company: 6084-Janssen Research & Development Legal Enti
Location: Spring House
Posted on: April 1, 2026
|
|
|
Job Description:
At Johnson & Johnson, we believe health is everything. Our
strength in healthcare innovation empowers us to build a world
where complex diseases are prevented, treated, and cured, where
treatments are smarter and less invasive, and solutions are
personal. Through our expertise in Innovative Medicine and MedTech,
we are uniquely positioned to innovate across the full spectrum of
healthcare solutions today to deliver the breakthroughs of
tomorrow, and profoundly impact health for humanity. Learn more at
jnj.com . As guided by Our Credo, Johnson & Johnson is responsible
to our employees who work with us throughout the world. We provide
an inclusive work environment where each person is considered as an
individual. At Johnson & Johnson, we respect the diversity and
dignity of our employees and recognize their merit. Job Function:
Discovery & Pre-Clinical/Clinical Development Job Sub Function:
Biotherapeutics R&D Job Category: Scientific/Technology All Job
Posting Locations: Spring House, Pennsylvania, United States of
America Job Description: About Innovative Medicine: Our expertise
in Innovative Medicine is informed and inspired by patients, whose
insights fuel our science-based advancements. Visionaries like you
work on teams that save lives by developing the medicines of
tomorrow. Join us in developing treatments, finding cures, and
pioneering the path from lab to life while championing patients
every step of the way. Learn more at
https://www.jnj.com/innovative-medicine We are searching for the
best talent for a Principal Scientist, Molecular Biology to be
onsite in Spring House, PA. Purpose: The in Vivo Antibody Discovery
group within Biologics Discovery is responsible for lead antibody
generation from immunized animals with state-of-the-art
technologies including single B cell sorting, hybridoma, display
and microfluidics. In this key role, the Principal Scientist will
lead a team responsible for recovery of antibody sequences from
selected hybridoma cells or single B cells . The candidate is
expected to work with automation experts to automate NGS workflow
for efficient sequence recovery. In-depth knowledge and extensive
experience in molecular cloning of BCR using various approaches
including RT-PCR, Topo cloning, in-fusion cloning, multiplex NGS,
10X genomics are required. A strong understanding of B-cell
recovery methods such as Hybridoma technology and primary B-cell
cloning will also be important. This is a critical function in a
multifaceted Biologics Discovery organization committed to bringing
the next generation of biotherapeutic molecules to patients. We are
looking for a motivated candidate with scientific and technical
expertise who can collaborate across discovery areas to bring value
to our portfolio of innovative drug concepts. Proficiency to work
within a highly coordinated, fast-paced environment will be a
significant attribute. If this sounds like you, come join our team!
You will be responsible for : Provide day-to-day in-person guidance
and mentoring within the V-Gene Recovery (VGR) team Lead antibody
sequence recovery from selected hits of diverse sources, including
hybridoma, single B cells, immune repertoires, and in vitro display
platforms. Execute and optimize molecular biology workflows,
including Next-Generation Sequencing (NGS) and conventional Sanger
sequencing, to enable efficient and accurate antibody discovery.
Work with automation experts to automate and streamline NGS
workflows, identifying opportunities for process improvements to
enhance sequencing accuracy and efficiency. Manage laboratory
operations by maintaining equipment, ensuring sufficient inventory
of supplies, and overseeing the routine maintenance of NGS
instruments and related laboratory equipment. Conduct comprehensive
data analysis, interpret sequencing results, and generate detailed
reports. Bioinformatics experience is a plus. Present research
findings in internal meetings, clearly communicating scientific
results and providing insights into data interpretation.
Collaborate with multidisciplinary teams across functional areas to
advance therapeutic programs, contributing scientific expertise to
multiple projects in a dynamic and fast-paced environment. Document
work accurately and promptly using Electronic Lab Notebook systems
(e.g., Signal) and generate protocols and SOPs. Work closely with
stakeholders and project managers to address operational needs and
ensure seamless workflow execution. Demonstrate scientific
curiosity and problem-solving skills, contributing to innovation
and continuous improvement in molecular biology and sequencing
workflows. Qualifications / Requirements: Education and Years of
Experience: Minimum of a Bachelor’s degree is required PhD in
Molecular Biology, Biomedical Engineering, Biochemistry or a
related field is highly preferred Required: Minimum 6 years of
experience in the pharmaceutical industry and/or academic setting
Team management experience Proficiency in molecular biology
techniques, including PCR, molecular cloning, and plasmid design.
Expertise with DNA sequencing (NGS, 10x Genomics, Sanger) and
sequence data analysis related to antibody discovery. Preferred:
Familiarity with techniques for antibody repertoire analysis and
single cell analysis. Knowledge of data management and
visualization tools for large datasets, and knowledge with
statistical analysis of NGS results. Knowledge on leveraging
repertoire sequencing from immunized animals for AI/ML-driven
antibody discovery Johnson & Johnson is an Equal Opportunity
Employer. All qualified applicants will receive consideration for
employment without regard to race, color, religion, sex, sexual
orientation, gender identity, age, national origin, disability,
protected veteran status or other characteristics protected by
federal, state or local law. We actively seek qualified candidates
who are protected veterans and individuals with disabilities as
defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson & Johnson is committed to providing an interview process
that is inclusive of our applicants’ needs. If you are an
individual with a disability and would like to request an
accommodation, external applicants please contact us via
https://www.jnj.com/contact-us/careers , internal employees contact
AskGS to be directed to your accommodation resource. LI-Onsite
Required Skills: Preferred Skills:
Keywords: 6084-Janssen Research & Development Legal Enti, Elizabeth , Principal Scientist, Molecular Biology, Science, Research & Development , Spring House, New Jersey
