Principal Scientist, Cardiovascular Translational - Princeton NJ

Company: Msccn
Location: Princeton
Posted on: April 1, 2026

Job Description:

Job Description ATTENTION MILITARY AFFILIATED JOB SEEKERS - Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers . If you have the required skill set, education requirements, and experience, please click the submit button and follow the next steps. Unless specifically stated otherwise, this role is "On-Site" at the location detailed in the job post. Position Summary: We are seeking a translational scientist with a background in cardiovascular biology to identify and discover novel and existing biomarkers to support the progression of late-discovery programs to early phase clinical trials and beyond. As such, this position will involve a close collaboration with the development organization. The translational scientist may serve as a liaison of discovery to development. The successful candidate will collaborate closely with early discovery team members to drive the progression of programs, which may include assisting the completion of pharmacology studies and guide the selection and analysis of endpoints to support an early translational development plan, including patient segmentation hypotheses. They will be able to apply their knowledge of cardiovascular biology and translational aspects of cardiovascular medicine to establish pharmacodynamic endpoints consistent with mechanism of action, which may involve in vivo, functional-structural analyses and ex vivo or in vitro biochemical or molecular assays, including the development of novel assays. The position may work with human samples or human-relevant systems to test translational hypotheses identified in support of biomarker plan development. This is primarily an on-site, lab-based position but time in lab may be dependent on programmatic needs as discovery programs progress to development, to be determined in collaboration with the manager. Position Responsibilities: Perform studies to define pharmacodynamic biomarkers of response and disease progression, as a member of a discovery team and can investigate and articulate how these biomarkers may translate to the clinic Thorough knowledge of experimental design, and a high level of technical laboratory skills (including cell culture of relevant cell lines and primary cells, immunoassays, such as ELISA/MSD, IHC, protein signaling, qPCR technology platforms) together with an ability to interpret results Employs technical knowledge and theory to make experimental in-life modifications, when necessary Lead studies to completion, including the hands-on analysis of samples internally or directing studies externally through management of CROs. Evaluate programs critically and present findings and recommendations to discovery teams and leadership Document, critically review, modify experimental approach, if necessary, and present experimental data in a timely manner. Collaborate with cross-functional teams by providing timely and actionable study results. Provide hands-on training and guidance to develop team members Contribute to and author reports, abstracts, and publications. Additional Qualifications/Responsibilities Experience = Basic Qualifications: Bachelor’s Degree 8 years of academic and / or industry experience Or Master’s Degree 6 years of academic and / or industry experience Or Ph.D. or equivalent advanced degree in the Life Sciences 4 years of academic and / or industry experience Preferred Qualifications: Ph.D. in Physiology, Pharmacology, Biology, Biochemistry, or a related field with 2 years of relevant industry experience and 5 years’ experience after completion of terminal degree, including post-doctoral training. PharmD/DVM/MD may be considered with a strong track record of achievement in the basic sciences or drug discovery from hands-on contributions. Alternatively, an M.S. in a related field with 5 years (after completion of degree) relevant industry experience. Strong understanding of cardiovascular physiology and modern cardiovascular methodologies (including those that may serve as pharmacodynamic endpoints) employed pre-clinically and clinically Includes a strong understanding of imaging biomarkers used in the clinic (eg ultrasound-echocardiography, MRI, and PET) An understanding of the considerations for the use of animals in research, with a focus species-specific use, and can articulate and apply 3Rs principles in designing and initiating experiments Hands-on experience handling rodents is necessary Expertise culturing and making biochemical and/or functional measurements in iPSC-CM, primary cardiac cells, and/or engineered heart tissues is necessary Excellent laboratory skills, prioritizing accurate and reproducible work. Skill in managing external collaborators and setting clear timelines and expectations Must be self-motivated, detail-oriented, collaborative, and able to work effectively in a multidisciplinary, matrixed team environment. LI-Onsite If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Princeton - NJ - US: $135,800 - $164,563

Keywords: Msccn, Elizabeth , Principal Scientist, Cardiovascular Translational - Princeton NJ, Science, Research & Development , Princeton, New Jersey